ABSTRACT. Papaya Carica papaya L. is widely cultivated in tropical and subtropical countries. Although ripe fruits are a popular food globally, unripe fruits are only eaten in some Asian countries. To promote the use of unripe papaya based on the compositional changes of active biological metabolites, we performed liquid treatment. Male papaya leaf juice was administered to prevent thrombocytopenia to MM groups, female papaya leaf juice was administered to F F5. From 14 blood samples, Carica papaya L. is a well-known fruit worldwide and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C and E, B-complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as dietary fiber. Phenolic compounds, such as benzyl, 1. Introduction. Carica papaya is the most produced fruit in the world, after bananas, oranges and mangoes. The annual production of papaya in India is. tons, which represents global production FAOSTAT, 2021. Papaya PL latex is collected from unripe leaves and fruits, which are rich, 1. Introduction. Papaya Carica papaya L. is one of the five most widely grown tropical fruit crops in tropical and subtropical regions around the world, including Australia, Hawaii, and Southeast Asia. The papaya fruit is juicy with a sweet flavor and the ripe fruit is rich in vitamins A. and C, folate, as well as calcium The fruit,